cell reports: CD8 + T cells in the gut microbes is affected by the differentiation helene blog de f

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cell reports: CD8 + T cells in the gut microbes is affected by the differentiation helene blog de fille of CD4 + Cloud Hospital "healthy year 2015" @ heart, said the new concept of medical bacteria development and maturation of T cells in the thymus is completed. Here they will be subject to "positive selection (positive selection)" as well as "negative selection (negative selection)", and thus the development of specific recognition of exogenous substances form mature T cells. At the same time, CD4 and CD8 differentiation is also done here. CD8 expression for a class T cell surface molecules in the future development of cytotoxic T cells (cytotoxic T cell), responsible for pathogen killing effect downstream. Another expression of surface molecules CD4 T cells in the future development of helper T cells (helper T cell), responsible for the role of signal transmission. Generally considered mature when they leave the thymus, CD8 and CD4 marker has been fixed, it is for any one clone can not be changed. Recently, however, the University helene blog de fille of Miami Miller School of Medicine, the study group Zhibin Chen "cell report" published an article found in gut-specific environment, there will be mature CD8 T cell differentiation into CD4-positive direction, and This differentiation for the regulation of immune tolerance have a positive effect.
Research helene blog de fille based on this question: the large intestine surface enrichment of a large number of micro-organisms, and thus the host of these microbes evolved the corresponding mechanism of immune tolerance. However, due to differences between microorganisms very limited, the authors believe that this type of immune tolerance helene blog de fille must be controlled within a certain range. Therefore, the authors conjecture whether the complex environment in the gut, the division of T cells no longer a "rigid" strategy, but may change with the environment and continuously adjust the "flexible" policy. First, the author of the whole breeding acquired immune system contains only one class only identify helene blog de fille a specific antigen CD8 + T cells in mice (A mice). Through the A mouse adult tissue dissection, helene blog de fille and take lymph node cell characterization (streaming). The results showed that although mice genetically containing only CD8 + T cells, but in the large intestine lymph nodes still see a considerable helene blog de fille part of the CD4 + T cells, it is interesting that this part of the cell with the original CD8 + T cells recognize the same antigen. Description This part of the "accident" appears CD4 + T cells are CD8 + cells from over. Thereafter, the author hybridization A mice missing the MHC-II's B mice were crossed to give the A & B mice. The same testing found: A & B mouse colon CD4 + T cells in the lymph nodes are no longer there. helene blog de fille Description This phenomenon is dependent on the cell surface helene blog de fille of MHC-II. On the other hand, although the authors found that the fact that the transition from CD4 to CD8, but not CD4 to CD8 can change. Thereafter, the author surgically way A mouse mesenteric lymph nodes (MLN) removed, showed that: compared with the control group, although the large intestine lymph node CD4 + T cells and the ratio of the total amount is not received after removal of the impact, but the Treg proportion undergone helene blog de fille significant decline. Thereafter, by means of genetic confirmed OF CD8 + T cells in the thymus and external MHC-II interaction can promote T cell differentiation to CD4 +. Thymus helene blog de fille no role in this process. The authors also found that gut microbes CD4 to CD8 transition to have a very important role, but after missing the intestinal microflora helene blog de fille and can stop this transformation. Description Starts factor in this process is not gut microbes. Further, since previous reports that TGF-beta plays an important role in the regulation of T cell differentiation, the detection of TGF-beta OF affect this transformation, the results show: blocking TGF-beta signaling pathway and does not inhibit the differentiation process , denied the speculation. Finally, authors demonstrated this phenomenon in the (T cell sound) the same physiological conditions exist, and through this process to produce proof of specific recognition helene blog de fille of MHC-I for the regulation of immune tolerance Treg has a positive effect. Lui JB, Devarajan P, Teplicki SA, Chen Z.Cross-Differentiation from the CD8 Lineage to CD4 T Cells in the Gut-Associated Microenvironment with a Nonessential Role of Microbiota.Cell Rep. 2015 Jan 27.

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